THE BEST SIDE OF PKRRATING

The interfacial residues are very conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display which the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations aid a design where by activating RNA serves to be a scaffold to bind various PKR monomers, raising the regi

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